Article
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.
DNA repair - 1 Jan 2015
Pettersen Henrik Sahlin, Galashevskaya Anastasia, Doseth Berit, Sousa Mirta M L, Sarno Antonio, Visnes Torkild, Aas Per Arne, Liabakk Nina-Beate, Slupphaug Geir, Sætrom Pål, Kavli Bodil, Krokan Hans E
Abstract excerpt
The most common mutations in cancer are C to T transitions, but their origin has remained elusive. Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many common cancers, suggesting off-target deamination of cytosine to uracil as a common mutagenic mechanism. Here we present evidence from mass spectrometric quantitation of deoxyuridine in DNA that shows significantly higher...
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