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Article

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma.

PLoS genetics - 1 Dec 2020

Delgado Pilar, Álvarez-Prado Ángel F, Marina-Zárate Ester, Sernandez Isora V, Mur Sonia M, de la Barrera Jorge, Sanchez-Cabo Fátima, Cañamero Marta, de Molina Antonio, Belver Laura, de Yébenes Virginia G, Ramiro Almudena R

Abstract excerpt

Most B cell lymphomas originate from B cells that have germinal center (GC) experience and bear chromosome translocations and numerous point mutations. GC B cells remodel their immunoglobulin (Ig) genes by somatic hypermutation (SHM) and class switch recombination (CSR) in their Ig genes. Activation Induced Deaminase (AID) initiates CSR and SHM by generating U:G mismatches on Ig DNA that can then be processed by...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33362210
DOI: 10.1371/journal.pgen.1008960
PMCID: PMC7790409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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