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Article

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation.

Cell - 15 Oct 2020

Zhu Guangya, Xie Jingjing, Kong Wenna, Xie Jingfei, Li Yichen, Du Lin, Zheng Qiangang, Sun Lin, Guan Mingfeng, Li Huan, Zhu Tianxin, He Hao, Liu Zhenying, Xia Xi, Kan Chen, Tao Youqi, Shen Hong C, Li Dan, Wang Siying, Yu Yongguo, Yu Zhi-Hong, Zhang Zhong-Yin, Liu Cong, Zhu Jidong

Abstract excerpt

The non-receptor protein tyrosine phosphatase (PTP) SHP2, encoded by PTPN11, plays an essential role in RAS-mitogen-activated protein kinase (MAPK) signaling during normal development. It has been perplexing as to why both enzymatically activating and inactivating mutations in PTPN11 result in human developmental disorders with overlapping clinical manifestations. Here, we uncover a common liquid-liquid phase...

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Identifiers

PMID: 33002410
DOI: 10.1016/j.cell.2020.09.002
PMCID: PMC7572904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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