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Article

Tyrosine 251 at the C-terminus of neuronal glycoprotein M6a is critical for neurite outgrowth.

Journal of neuroscience research - 1 Feb 2015

Formoso Karina, Billi Silvia C, Frasch Alberto C, Scorticati Camila

Abstract excerpt

Neuronal glycoprotein M6a is involved in neuronal plasticity, promoting neurite and filopodia outgrowth and, likely, synaptogenesis. Polymorphisms in the human M6a gene GPM6A have recently been associated with mental illnesses such as schizophrenia, bipolar disorders, and claustrophobia. Nevertheless, the molecular bases underlying these observations remain unknown. We have previously documented that, to induce...

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PMID: 25242528
DOI: 10.1002/jnr.23482

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