Article
Structure of the MRAS-SHOC2-PP1C phosphatase complex.
Nature - 1 Sept 2022
Hauseman Zachary J, Fodor Michelle, Dhembi Anxhela, Viscomi Jessica, Egli David, Bleu Melusine, Katz Stephanie, Park Eunyoung, Jang Dong Man, Porter Kathryn A, Meili Fabian, Guo Hongqiu, Kerr Grainne, Mollé Sandra, Velez-Vega Camilo, Beyer Kim S, Galli Giorgio G, Maira Saveur-Michel, Stams Travis, Clark Kirk, Eck Michael J, Tordella Luca, Thoma Claudio R, King Daniel A
Abstract excerpt
RAS-MAPK signalling is fundamental for cell proliferation and is altered in most human cancers1-3. However, our mechanistic understanding of how RAS signals through RAF is still incomplete. Although studies revealed snapshots for autoinhibited and active RAF-MEK1-14-3-3 complexes4, the intermediate steps that lead to RAF activation remain unclear. The MRAS-SHOC2-PP1C holophosphatase dephosphorylates RAF at serine...
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