Article

Allosteric inhibition rescues hydrocephalus caused by catalytically inactive Shp2

2025-02-01

Abstract excerpt

SHP2, a protein tyrosine phosphatase (PTP) crucial in Ras-MAPK signaling, is associated with various human congenital diseases and cancers. Here, we show that the catalytically inactive Shp2 C459S mutation results in communicating hydrocephalus, similar to the catalytically activating Shp2 E76K and Mek1 DD mutants. Unlike previous mutants, however, Shp2 C459S/+ mutation uniquely affects ciliary development...

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Literature Corpus work: bcd01a1e-b5b1-5c5a-9f7b-a9ce0b0f1273
DOI: 10.1101/2025.01.28.635289

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