Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.

Basic & clinical pharmacology & toxicology - 1 Jul 2015

Dai Da-Peng, Geng Pei-Wu, Wang Shuang-Hu, Cai Jie, Hu Li-Ming, Nie Jing-Jing, Hu Ji-Hong, Hu Guo-Xin, Cai Jian-Ping

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is one of the most widely investigated CYPs related to genetic polymorphisms and is responsible for one-quarter of the currently used clinical drugs. We previously detected 22 novel, non-synonymous, mutated sites in the Chinese population, but nothing is known about the functional effects of these mutations in terms of specific CYP2D6 substrates. In this study, wild-type CYP2D6, two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to China

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2D6

Share to Dextromethorphan

Share to Ethanolamines

Share to HEK293 Cells

Share to Substrate Specificity

Share to Transfection

Source

Identifiers

PMID: 25469868
DOI: 10.1111/bcpt.12363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.PMID 25469868Read ↗

Identification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population.Semantic proximity Read ↗

Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro.Semantic proximity Read ↗

Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.Semantic proximity Read ↗

Functional influence of human CYP2D6 allelic variations: P34S, E418K, S486T, and R296C.Semantic proximity Read ↗

Functional characterization of CYP2D6 novel allelic variants identified in the Chinese Han population.Semantic proximity Read ↗

CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.Semantic proximity Read ↗

Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese.Semantic proximity Read ↗

A Review of the Important Role of CYP2D6 in Pharmacogenomics.Semantic proximity Read ↗

Genetic polymorphisms analysis of CYP2D6 in the Uygur population.Semantic proximity Read ↗

Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine.Semantic proximity Read ↗

Effect of 22 CYP2D6 variants found in the Chinese population on tolterodine metabolism in vitro.Semantic proximity Read ↗

Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.