Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of CYP2D6 novel allelic variants identified in the Chinese Han population.

Pharmacogenomics - 1 Jan 2016

Xu Qingqing, Wu Zhenqiang, Yang Lun, Zhang Xiaoqing, Gai Zhongtao, Chen Lili, He Lin, Qin Shengying

Abstract excerpt

AIM: This study was aimed to functionally characterize four novel CYP2D6 alleles identified in Chinese Han population. MATERIALS & METHODS: CYP2D6 proteins of wild-type and the four novel variants along with CYP2D6.2 and CYP2D6.10 were heterologously expressed in yeast cells and the kinetic parameters were determined. RESULTS: Compared with CYP2D6.1 (frequency in Chinese 24.65%), CYP2D6.X (1.63%), CYP2D6.Y...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Asian People
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Debrisoquin

Share to Genetic Variation

Share to Recombinant Proteins

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 26652007
DOI: 10.2217/pgs.15.148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of CYP2D6 novel allelic variants identified in the Chinese Han population.PMID 26652007Read ↗

Genetic variations of human CYP2D6 in the Chinese Han population.Semantic proximity Read ↗

In vitro functional assessment of 22 newly identified CYP2D6 allelic variants in the Chinese population.Semantic proximity Read ↗

Genetic polymorphisms analysis of CYP2D6 in the Uygur population.Semantic proximity Read ↗

Nomenclature for human CYP2D6 alleles.Semantic proximity Read ↗

Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance.Semantic proximity Read ↗

Identification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population.Semantic proximity Read ↗

Single nucleotide and structural variants of CYP2D6 gene in Kinh Vietnamese populationSemantic proximity Read ↗

The frequencies of mutated alleles of CYP2D6 gene in a Turkish population.Semantic proximity Read ↗

CYP2D6 allele frequencies in Korean population, comparison with East Asian, Caucasian and African populations, and the comparison of metabolic activity of CYP2D6 genotypes.Semantic proximity Read ↗

Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.Semantic proximity Read ↗

CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants.Semantic proximity Read ↗

Polymorphisms and phenotypic analysis of cytochrome P450 2D6 in the Tibetan population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.