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Article

Functional influence of human CYP2D6 allelic variations: P34S, E418K, S486T, and R296C.

Archives of pharmacal research - 1 Dec 2013

Kim Joohwan, Lim Young-Ran, Han Songhee, Han Jung-Soo, Chun Young-Jin, Yun Chul-Ho, Lee Chang Hoon, Kim Donghak

Abstract excerpt

CYP2D6 is responsible for the oxidative metabolism of 20-25 % of clinical drugs and its genetic polymorphisms can significantly influence the drug metabolism. In this study, we analyzed the functional activities of four nonsynonymous single nucleotide polymorphisms from CYP2D6*52 allele, which were recently found, and one found frequently in CYP2D6 alleles. Recombinant variant enzymes of E418K, S486T, and R296C...

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Source

Identifiers

PMID: 23897164
DOI: 10.1007/s12272-013-0212-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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