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Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro.

Basic & clinical pharmacology & toxicology - 1 Mar 2016

Cai Jie, Dai Da-Peng, Geng Pei-Wu, Wang Shuang-Hu, Wang Hao, Zhan Yun-Yun, Huang Xiang-Xin, Hu Guo-Xin, Cai Jian-Ping

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic enzyme that metabolizes a large number of therapeutic drugs. To date, more than 100 CYP2D6 allelic variants have been reported. Among these variants, we recently identified 22 novel variants in the Chinese population. The aim of this study was to functionally characterize the enzymatic activity of these variants in vitro. A baculovirus-mediated expression...

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PMID: 26310775
DOI: 10.1111/bcpt.12478

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