Article
Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese.
Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2009
Matsunaga Masayuki, Yamazaki Hiroshi, Kiyotani Kazuma, Iwano Shunsuke, Saruwatari Jyunji, Nakagawa Kazuko, Soyama Akiko, Ozawa Shogo, Sawada Jun-Ichi, Kashiyama Eiji, Kinoshita Moritoshi, Kamataki Tetsuya
Abstract excerpt
During the course of sequencing for the CYP2D6 gene, we found a novel single nucleotide polymorphism of g.3318G>A (E383K) associated with CYP2D6*10, termed as CYP2D6*72. We also found a g.1611T>A (F120I) in the CYP2D6*49, which was previously identified as a CYP2D6*10-associated allele in an independent Japanese population. To clarify the effects of these novel CYP2D6*10 haplotypes on the functions of CYP2D6,...
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