Article
Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine.
Drug design, development and therapy - 1 Jan 2016
Xu Ren-ai, Gu Er-min, Zhou Quan, Yuan Lingjing, Hu Xiaoxia, Cai Jianping, Hu Guoxin
Abstract excerpt
BACKGROUND: CYP2D6 is one of the most important members of the cytochrome P450 superfamily. Its genetic polymorphism significantly influences the efficacy and safety of some drugs, which might cause adverse effects and therapeutic failure. METHODS AND RESULTS: The aim of this research was mainly to explore the catalytic activities of 22 newly reported CYP2D6 isoforms (2D6*87, *88, *89, *90, *91, *92, *93, *94,...
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