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Article

Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2009

Lee Su-Jun, Lee Sang Seop, Jung Hyun-Ju, Kim Ho-Sook, Park Soo-Jin, Yeo Chang-Woo, Shin Jae-Gook

Abstract excerpt

Our objectives were to identify CYP2D6 genetic polymorphisms in a Korean population, to compare the allele frequencies with those of other ethnic groups, and to evaluate variant-induced functional variations in dextromethorphan (DM) metabolism in vitro and in vivo. Thirty-eight single nucleotide polymorphisms of CYP2D6 were identified by direct DNA sequencing in 51 Koreans. An extended set of 707 subjects were...

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Identifiers

PMID: 19364831
DOI: 10.1124/dmd.108.022368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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