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Article

Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals.

Biochemical pharmacology - 1 Nov 2024

Yamazaki Shuki, Hishinuma Eiji, Suzuki Yuma, Ueda Akiko, Kijogi Caroline, Nakayoshi Tomoki, Oda Akifumi, Saito Sakae, Tadaka Shu, Kinoshita Kengo, Maekawa Masamitsu, Sato Yu, Kumondai Masaki, Mano Nariyasu, Hirasawa Noriyasu, Hiratsuka Masahiro

Abstract excerpt

Cytochrome P450 2B6 (CYP2B6) catalyzes the metabolism of many drugs, including efavirenz and propofol. Genetic polymorphisms in CYP2B6 alter its enzymatic activity and substantially affect its pharmacokinetics. High-frequency variants, such as CYP2B6*6, are associated with the risk of developing side effects due to reduced CYP2B6 activity. However, the impact of rare alterations on enzyme function remains...

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Identifiers

PMID: 39218044
DOI: 10.1016/j.bcp.2024.116515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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