Article
Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.
Experimental hematology - 1 Jan 2015
Nowak Daniel, Liem Natalia L M, Mossner Maximilian, Klaumünzer Marion, Papa Rachael A, Nowak Verena, Jann Johann C, Akagi Tadayuki, Kawamata Norihiko, Okamoto Ryoko, Thoennissen Nils H, Kato Motohiro, Sanada Masashi, Hofmann Wolf-Karsten, Ogawa Seishi, Marshall Glenn M, Lock Richard B, Koeffler H Phillip
Abstract excerpt
The use of genome-wide copy-number analysis and massive parallel sequencing has revolutionized the understanding of the clonal architecture of pediatric acute lymphoblastic leukemia (ALL) by demonstrating that this disease is composed of highly variable clonal ancestries following the rules of Darwinian selection. The current study aimed to analyze the molecular composition of childhood ALL biopsies and...
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