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Article

Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment.

Blood - 18 Aug 2011

Schmitz Maike, Breithaupt Petra, Scheidegger Nastassja, Cario Gunnar, Bonapace Laura, Meissner Barbara, Mirkowska Paulina, Tchinda Joelle, Niggli Felix K, Stanulla Martin, Schrappe Martin, Schrauder Andre, Bornhauser Beat C, Bourquin Jean-Pierre

Abstract excerpt

Clonal evolution of the leukemogenic compartment may contribute to alter the therapeutic response in acute lymphoblastic leukemia (ALL). Using xenotransplantation of primary leukemia cells, we evaluated the phenotypic and genetic composition of de novo resistant very high risk precursor B-cell ALL, a subgroup defined by the persistence of minimal residual disease despite intensive chemotherapy. Analysis of copy...

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PMID: 21670474
DOI: 10.1182/blood-2010-11-320309

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