Article
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.
Blood - 15 Nov 2008
Yang Jun J, Bhojwani Deepa, Yang Wenjian, Cai Xiangjun, Stocco Gabriele, Crews Kristine, Wang Jinhua, Morrison Debra, Devidas Meenakshi, Hunger Stephen P, Willman Cheryl L, Raetz Elizabeth A, Pui Ching-Hon, Evans William E, Relling Mary V, Carroll William L
Abstract excerpt
The underlying pathways that lead to relapse in childhood acute lymphoblastic leukemia (ALL) are unknown. To comprehensively characterize the molecular evolution of relapsed childhood B-precursor ALL, we used human 500K single-nucleotide polymorphism arrays to identify somatic copy number alterations (CNAs) in 20 diagnosis/relapse pairs relative to germ line. We identified 758 CNAs, 66.4% of which were less than...
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