RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences.

doi:10.1016/j.bbrc.2014.11.043

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Article

RNA polymerase III control elements are required for trans-activation by the murine retroviral long terminal repeat sequences.

Biochemical and biophysical research communications - 2 Jan 2015

Hwang Yong-Woo, Yoo Na Kyung, Yang Heung Mo, Choi Sang-Yun

Abstract excerpt

RNA leukemia viruses induce T-cell lymphoblastic lymphomas or myeloid leukemias. Infection of cells with Moloney murine leukemia virus (M-MuLV) up-regulates the expression of a number of cellular genes, including those involved in T-lymphocyte activation. Previously, we demonstrated that this up-regulation occurs via the trans-activation activity of the M-MuLV long terminal repeat (LTR) sequences which produce an...

Topics

3T3 Cells
Animals
Cell Line, Tumor
Cell Nucleus
Flow Cytometry
Gene Deletion
Gene Expression Regulation
Green Fluorescent Proteins
HeLa Cells
Humans
Jurkat Cells
Mice
Mice, Inbred BALB C
Moloney murine leukemia virus

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Open in PubMed

Identifiers

PMID: 25446107
DOI: 10.1016/j.bbrc.2014.11.043

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Mutation

Plasmids

RNA Polymerase III

Retroviridae