Mutations that abrogate transactivational activity of the feline leukemia virus long terminal repeat do not affect virus replication.

doi:10.1016/s0042-6822(03)00069-2

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Article

Mutations that abrogate transactivational activity of the feline leukemia virus long terminal repeat do not affect virus replication.

Virology - 10 May 2003

Abujamra Ana L, Faller Douglas V, Ghosh Sajal K

Abstract excerpt

The U3 region of the LTR of oncogenic Moloney murine leukemia virus (Mo-MuLV) and feline leukemia viruses (FeLV) have been previously reported to activate expression of specific cellular genes in trans, such as MHC class I, collagenase IV, and MCP-1, in an integration-independent manner. It has been suggested that transactivation of these specific cellular genes by leukemia virus U3-LTR may contribute to the...

Topics

3T3 Cells
Animals
Base Sequence
Cats
Cell Line
Chemokine CCL2
Collagenases
Gene Expression Regulation
Leukemia Virus, Feline
Mice
Molecular Sequence Data
Mutation
Terminal Repeat Sequences
Transcriptional Activation
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 12758176
DOI: 10.1016/s0042-6822(03)00069-2

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