Article
Marked Variation in Response of Consensus Binding Elements for the Rta Protein of Epstein-Barr Virus
13 Jul 2005
Abstract excerpt
The R transactivator (Rta) protein activates Epstein-Barr virus (EBV) lytic-cycle genes by several distinct mechanisms that include direct binding to viral promoters, synergy with BamHI Z EBV replication activator (ZEBRA), and activation of cellular signaling pathways. In the direct and synergistic mechanisms of action, Rta binds to specific DNA sequences that are present in the promoters of responsive genes. It...
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