ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer.

doi:10.1128/JVI.02253-06

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Article

ALY is a common coactivator of RUNX1 and c-Myb on the type B leukemogenic virus enhancer.

Journal of virology - 1 Apr 2007

Mertz Jennifer A, Kobayashi Ryuji, Dudley Jaquelin P

Abstract excerpt

Type B leukemogenic virus (TBLV), a mouse mammary tumor virus (MMTV) variant, often induces T-cell leukemias and lymphomas by c-myc activation following viral DNA integration. Transfection assays using a c-myc reporter plasmid indicated that the TBLV long terminal repeat (LTR) enhancer is necessary for T-cell-specific increases in basal reporter activity. The sequence requirements for this effect were studied...

Topics

Animals
Binding Sites
Cell Line
Core Binding Factor Alpha 2 Subunit
Enhancer Elements, Genetic
Humans
Mice
Molecular Sequence Data
Mutation
Nuclear Proteins
Promoter Regions, Genetic
Protein Binding
Proto-Oncogene Proteins c-myb
RNA-Binding Proteins
Retroviridae
Transcription Factors
Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 17229714
DOI: 10.1128/JVI.02253-06
PMCID: PMC1866045

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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