Article
Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice.
Learning & memory (Cold Spring Harbor, N.Y.) - 15 Nov 2012
Endres Thomas, Lessmann Volkmar
Abstract excerpt
Beyond its trophic function, the neurotrophin BDNF (brain-derived neurotrophic factor) is well known to crucially mediate synaptic plasticity and memory formation. Whereas recent studies suggested that acute BDNF/TrkB signaling regulates amygdala-dependent fear learning, no impairments of cued fear learning were reported in heterozygous BDNF knock-out mice (BDNF(+/-)). Since brain BDNF levels are known to decline...
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