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Article

Dorsomedial Prefrontal Cortex Mediates the Impact of Serotonin Transporter Linked Polymorphic Region Genotype on Anticipatory Threat Reactions.

Biological psychiatry - 15 Oct 2015

Klumpers Floris, Kroes Marijn C, Heitland Ivo, Everaerd Daphne, Akkermans Sophie E A, Oosting Ronald S, van Wingen Guido, Franke Barbara, Kenemans J Leon, Fernández Guillén, Baas Johanna M P

Abstract excerpt

BACKGROUND: Excessive anticipatory reactions to potential future adversity are observed across a range of anxiety disorders, but the neurogenetic mechanisms driving interindividual differences are largely unknown. We aimed to discover and validate a gene-brain-behavior pathway by linking presumed genetic risk for anxiety-related psychopathology, key neural activity involved in anxious anticipation, and resulting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25444169
DOI: 10.1016/j.biopsych.2014.07.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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