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Article

'Negativity bias' in risk for depression and anxiety: brain-body fear circuitry correlates, 5-HTT-LPR and early life stress.

NeuroImage - 1 Sept 2009

Williams Leanne M, Gatt Justine M, Schofield Peter R, Olivieri Gloria, Peduto Anthony, Gordon Evian

Abstract excerpt

The INTEGRATE Model draws on the framework of 'integrative neuroscience' to bring together brain-body and behavioral concepts of emotion, thinking and feeling and their regulation. The key organizing principle is the drive to 'minimize danger and maximize reward' that determines what is significant to us at each point in time. Traits of 'negativity bias' reflect the tendency to perceive danger rather than reward...

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Identifiers

PMID: 19446647
DOI: 10.1016/j.neuroimage.2009.05.009

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HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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