Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jul 2021

Tomasi Julia, Zai Clement C, Zai Gwyneth, Kennedy James L, Tiwari Arun K

Abstract excerpt

OBJECTIVES: Startle response is an objective physiological measure integral to the human defense system and a promising target for endophenotype investigations of anxiety. Given the alterations in startle reactivity observed among anxiety and related disorders, we searched for genetic variants associated with startle reactivity as they may be further involved in pathological anxiety risk. METHODS: A systematic...

Topics

Anxiety
Anxiety Disorders
Catechol O-Methyltransferase
Endophenotypes
Genotype
Humans
Reflex, Startle
Serotonin Plasma Membrane Transport Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33040669
DOI: 10.1080/15622975.2020.1834619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics of human startle reactivity: A systematic review to acquire targets for an anxiety endophenotype.PMID 33040669Read ↗

The effect of polymorphisms in startle-related genes on anxiety symptom severity.Semantic proximity Read ↗

Startle response related genes.Semantic proximity Read ↗

Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle.Semantic proximity Read ↗

Genetics of anxiety disorders - status quo and quo vadis.Semantic proximity Read ↗

BDNF val(66)met genotype shows distinct associations with the acoustic startle reflex and the cortisol stress response in young adults and children.Semantic proximity Read ↗

Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety.Semantic proximity Read ↗

COMT genetic variation affects fear processing: psychophysiological evidence.Semantic proximity Read ↗

Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic lociSemantic proximity Read ↗

Asians demonstrate reduced sensitivity to unpredictable threat: a preliminary startle investigation using genetic ancestry in a multiethnic sample.Semantic proximity Read ↗

Genetic factors in anxiety disorders.Semantic proximity Read ↗

Dorsomedial Prefrontal Cortex Mediates the Impact of Serotonin Transporter Linked Polymorphic Region Genotype on Anticipatory Threat Reactions.Semantic proximity Read ↗

Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.