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Article

The interplay of protein kinase A and perilipin 5 regulates cardiac lipolysis.

The Journal of biological chemistry - 16 Jan 2015

Pollak Nina M, Jaeger Doris, Kolleritsch Stephanie, Zimmermann Robert, Zechner Rudolf, Lass Achim, Haemmerle Guenter

Abstract excerpt

Defective lipolysis in mice lacking adipose triglyceride lipase provokes severe cardiac steatosis and heart dysfunction, markedly shortening life span. Similarly, cardiac muscle (CM)-specific Plin5 overexpression (CM-Plin5) leads to severe triglyceride (TG) accumulation in cardiomyocytes via impairing TG breakdown. Interestingly, cardiac steatosis due to overexpression of Plin5 is compatible with normal heart...

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Identifiers

PMID: 25418045
DOI: 10.1074/jbc.M114.604744
PMCID: PMC4340377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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