Article
Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis.
The Journal of biological chemistry - 19 Dec 2003
Zhang Hui H, Souza Sandra C, Muliro Kizito V, Kraemer Fredric B, Obin Martin S, Greenberg Andrew S
Abstract excerpt
Perilipin (Peri) A is a lipid droplet-associated phosphoprotein that acts dually as a suppressor of basal (constitutive) lipolysis and as an enhancer of cyclic AMP-dependent protein kinase (PKA)-stimulated lipolysis by both hormone-sensitive lipase (HSL) and non-HSL(s). To identify domains of Peri A that mediate these multiple actions, we introduced adenoviruses expressing truncated or mutated Peri A and HSL into...
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