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Article

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

Science signaling - 24 Jan 2017

Nystoriak Matthew A, Nieves-Cintrón Madeline, Patriarchi Tommaso, Buonarati Olivia R, Prada Maria Paz, Morotti Stefano, Grandi Eleonora, Fernandes Julia Dos Santos, Forbush Katherine, Hofmann Franz, Sasse Kent C, Scott John D, Ward Sean M, Hell Johannes W, Navedo Manuel F

Abstract excerpt

Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1.2 channels. In murine arterial myocytes, kinase-dependent mechanisms mediate the increase in CaV1.2 activity in response to increased extracellular glucose. We identified a subpopulation of the CaV1.2 channel pore-forming subunit (α1C)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28119464
DOI: 10.1126/scisignal.aaf9647
PMCID: PMC5297430

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