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Article

ULK1 prevents cardiac dysfunction in obesity through autophagy-meditated regulation of lipid metabolism.

Cardiovascular research - 1 Aug 2017

An Minae, Ryu Dong-Ryeol, Won Park Jang, Ha Choi Ji, Park Eun-Mi, Eun Lee Kyung, Woo Minna, Kim Minsuk

Abstract excerpt

AIMS: Autophagy is essential to maintain tissue homeostasis, particularly in long-lived cells such as cardiomyocytes. Whereas many studies support the importance of autophagy in the mechanisms underlying obesity-related cardiac dysfunction, the role of autophagy in cardiac lipid metabolism remains unclear. In the heart, lipotoxicity is exacerbated by cardiac lipoprotein lipase (LPL), which mediates accumulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28430962
DOI: 10.1093/cvr/cvx064

Genes

LPL
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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