Article
Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.
Cell reports - 15 May 2018
Xia Wenmin, Pessentheiner Ariane R, Hofer Dina C, Amor Melina, Schreiber Renate, Schoiswohl Gabriele, Eichmann Thomas O, Walenta Evelyn, Itariu Bianca, Prager Gerhard, Hackl Hubert, Stulnig Thomas, Kratky Dagmar, Rülicke Thomas, Bogner-Strauss Juliane G
Abstract excerpt
Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for the anti-lipolytic action of insulin in white adipose tissue (WAT). Neither insulin nor glucose treatments can suppress FA mobilization in global and conditional...
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