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Article

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.

Journal of lipid research - 1 Jun 2007

Souza Sandra C, Christoffolete Marcelo A, Ribeiro Miriam O, Miyoshi Hideaki, Strissel Katherine J, Stancheva Zlatina S, Rogers Nicole H, D'Eon Tara M, Perfield James W, Imachi Hitomi, Obin Martin S, Bianco Antonio C, Greenberg Andrew S

Abstract excerpt

In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis). NE-induced lipolysis is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin, a lipid droplet-associated protein that is the major regulator of lipolysis. We investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17401109
DOI: 10.1194/jlr.M700047-JLR200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.PMID 17401109Read ↗

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