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Article

Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2015

Ohgami Robert S, Ma Lisa, Merker Jason D, Gotlib Jason R, Schrijver Iris, Zehnder James L, Arber Daniel A

Abstract excerpt

We assessed the frequency and clinicopathologic significance of 19 genes currently identified as significantly mutated in myeloid neoplasms, RUNX1, ASXL1, TET2, CEBPA, IDH1, IDH2, DNMT3A, FLT3, NPM1, TP53, NRAS, EZH2, CBL, U2AF1, SF3B1, SRSF2, JAK2, CSF3R, and SETBP1, across 93 cases of acute myeloid leukemia (AML) using capture target enrichment and next-generation sequencing. Of these cases, 79% showed at least...

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Source

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Identifiers

PMID: 25412851
DOI: 10.1038/modpathol.2014.160
PMCID: PMC5436901

Genes

ASXL1
TET2
CBL
FLT3
IDH1
IDH2
JAK2
NPM1
NRAS
RUNX1
SETBP1
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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