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Landscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia

16 Mar 2020

Abstract excerpt

Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic instability. Next-generation sequencing has significantly improved the ability of diagnostic research to molecularly characterize and stratify patients. This detailed outcome allowed the discovery of new therapeutic targets and predictive biomarkers, which led to develop novel compounds (e.g., IDH 1 and 2 inhibitors), nowadays...

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PMID: 32188030
DOI: 10.3390/jcm9030802

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