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Article

Myeloid malignancies: mutations, models and management.

BMC cancer - 23 Jul 2012

Murati Anne, Brecqueville Mandy, Devillier Raynier, Mozziconacci Marie-Joelle, Gelsi-Boyer Véronique, Birnbaum Daniel

Abstract excerpt

Myeloid malignant diseases comprise chronic (including myelodysplastic syndromes, myeloproliferative neoplasms and chronic myelomonocytic leukemia) and acute (acute myeloid leukemia) stages. They are clonal diseases arising in hematopoietic stem or progenitor cells. Mutations responsible for these diseases occur in several genes whose encoded proteins belong principally to five classes: signaling pathways...

Topics

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Cell Transformation, Neoplastic
CBL gene
ETV6 gene
Leukemia, Myeloid
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Myeloproliferative Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 22823977
DOI: 10.1186/1471-2407-12-304
PMCID: PMC3418560

Genes

ASXL1
CBL
ETV6
FLT3
IDH1
IDH2
JAK2
RUNX1
SRSF2
SUZ12
TET2

Provenance

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