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Article

Targeted next generation sequencing and identification of risk factors in World Health Organization defined atypical chronic myeloid leukemia.

American journal of hematology - 1 Jun 2017

Patnaik Mrinal M, Barraco Daniela, Lasho Terra L, Finke Christy M, Reichard Kaaren, Hoversten Katherine P, Ketterling Rhett P, Gangat Naseema, Tefferi Ayalew

Abstract excerpt

Atypical chronic myeloid leukemia (aCML) is an aggressive myeloid neoplasm with overlapping features of myelodysplastic syndromes (prominent granulocytic dysplasia) and myeloproliferative neoplasms (neutrophilic leukocytosis). We studied 25 molecularly-annotated and World Health Organization defined aCML patients; median age 70 years, 84% males. Cytogenetic abnormalities were seen in 36% and gene mutations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28314085
DOI: 10.1002/ajh.24722
PMCID: PMC5422114

Genes

TET2
ASXL1
ETNK1
NRAS
PTPN11
SETBP1
RUNX1

Provenance

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