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Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia.

Scientific reports - 22 Jul 2020

Wang Shujuan, Wu Zhenzhen, Li Tao, Li Yafei, Wang Weiqiong, Hao Qianqian, Xie Xinsheng, Wan Dingming, Jiang Zhongxing, Wang Chong, Liu Yanfang

Abstract excerpt

The mutational spectrum and prognostic factors of NRAS-mutated (NRASmut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovered 152 NRASmut AML (13%). Of the 152 NRASmut AML, 89% had at least one companion mutated gene. DNA methylation-related genes confer up to 62% incidence. TET2 had the highest mutation frequency (51%),...

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Dioxygenases
Disease-Free Survival
GTP Phosphohydrolases
Kaplan-Meier Estimate
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

Splicing Factor U2AF

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PMID: 32699322
DOI: 10.1038/s41598-020-69194-6
PMCID: PMC7376066

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