Article
Impact of the variant allele frequency of ASXL1, DNMT3A, JAK2, TET2, TP53, and NPM1 on the outcomes of patients with newly diagnosed acute myeloid leukemia.
Cancer - 15 Feb 2020
Sasaki Koji, Kanagal-Shamanna Rashmi, Montalban-Bravo Guillermo, Assi Rita, Jabbour Elias, Ravandi Farhad, Kadia Tapan, Pierce Sherry, Takahashi Koichi, Nogueras Gonzalez Graciela, Patel Keyur, Soltysiak Kelly A, Cortes Jorge, Kantarjian Hagop M, Garcia-Manero Guillermo
Abstract excerpt
BACKGROUND: The impact of the allelic burden of ASXL1, DNMT3A, JAK2, TET2, and TP53 mutations on survival remains unclear in patients with newly diagnosed acute myeloid leukemia (AML). METHODS: The authors assessed bone marrow aspirates from 421 patients with newly diagnosed AML using next-generation sequencing for ASXL1, DNMT3A, JAK2, TET2, and TP53 mutations, defined as the presence of mutations in ASXL1,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.