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Article

MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer.

International journal of cancer - 15 Jun 2015

Renaud Florence, Vincent Audrey, Mariette Christophe, Crépin Michel, Stechly Laurence, Truant Stéphanie, Copin Marie-Christine, Porchet Nicole, Leteurtre Emmanuelle, Van Seuningen Isabelle, Buisine Marie-Pierre

Abstract excerpt

Colorectal cancers (CRC) with microsatellite instability (MSI) display unique clinicopathologic features including a mucinous pattern with frequent expression of the secreted mucins MUC2 and MUC5AC. The mechanisms responsible for this altered pattern of expression remain largely unknown. We quantified DNA methylation of mucin genes (MUC2, MUC5AC, MUC4) in colonic cancers and examined the association with...

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Identifiers

PMID: 25403854
DOI: 10.1002/ijc.29342

Genes

MUC2
BRAF
KRAS
MUC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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