Article
BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer.
International journal of cancer - 1 Jun 2006
Tanaka Hirofumi, Deng Guoren, Matsuzaki Koji, Kakar Sanjay, Kim Grace E, Miura Soichiro, Sleisenger Marvin H, Kim Young S
Abstract excerpt
Mucinous colorectal cancer (CRC) has been reported to have distinct clinicopathological and genetic characteristics. However, the incidence and the relationship among microsatellite instability (MSI), CpG island methylator phenotype (CIMP) and BRAF and KRAS mutations in mucinous and non-mucinous CRC are not known. Activating mutations of BRAF and KRAS and their relationship with MSI and CIMP were examined in 83...
Topics
- Adenocarcinoma, Mucinous
- Aged
- Aged, 80 and over
- Colonic Neoplasms
- CpG Islands
- DNA Methylation
- DNA Mutational Analysis
- Epigenesis, Genetic
- Female
- Genomic Instability