Article
The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential.
International journal of cancer - 15 Mar 2016
Renaud Florence, Mariette Christophe, Vincent Audrey, Wacrenier Agnès, Maunoury Vincent, Leclerc Julie, Coppin Lucie, Crépin Michel, Van Seuningen Isabelle, Leteurtre Emmanuelle, Buisine Marie-Pierre
Abstract excerpt
The serrated neoplasia pathway accounts for 20-30% of colorectal cancers (CRC), which are characterized by extensive methylation (CpG island methylation phenotype, CIMP), frequent BRAF mutation and high microsatellite instability (MSI). We recently identified MUC5AC mucin gene hypomethylation as a specific marker of MSI CRC. The early identification of preneoplastic lesions among serrated polyps is currently...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.