Article
Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2013
Walsh Michael D, Clendenning Mark, Williamson Elizabeth, Pearson Sally-Ann, Walters Rhiannon J, Nagler Belinda, Packenas David, Win Aung K, Hopper John L, Jenkins Mark A, Haydon Andrew M, Rosty Christophe, English Dallas R, Giles Graham G, McGuckin Michael A, Young Joanne P, Buchanan Daniel D
Abstract excerpt
Mucinous differentiation is associated with both CpG island methylator phenotype and microsatellite instability in colorectal cancer. The mucinous phenotype derives from abundant expression of the colonic goblet cell mucin, MUC2, and de novo expression of gastric foveolar mucin, MUC5AC. We, therefore, investigated the protein expression levels of MUC2 and MUC5AC, as well as MUC5B and MUC6, in molecular subtypes...
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