Article
A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers.
International journal of cancer - 1 Mar 2012
Silver Andrew, Sengupta Neel, Propper David, Wilson Peter, Hagemann Thorsten, Patel Asif, Parker Alexandra, Ghosh Anil, Feakins Roger, Dorudi Sina, Suraweera Nirosha
Abstract excerpt
Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are well-characterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup is also a feature of non-MSI cancers. A large proportion of CRCs have no evidence of either MSI or CIN, here called Microsatellite...
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