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Detection and clinical significance of CEACAM5 methylation in colorectal cancer patients

9 Nov 2023

Abstract excerpt

Colorectal cancer (CRC) is a globally common cancer, and the serum carcinoembryonic antigen (sCEA) is widely applied as a diagnostic and prognostic tumor marker in CRC. This study aimed to elucidate the mechanism of CEA expression and corresponding clinical features to improve prognostic assessments. In CRC cells, hypomethylation of the CEACAM5 promoter enhanced CEA expression in HCT116 and HT29 cells with...

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PMID: 37942534
DOI: 10.1111/cas.16012

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