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DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability

25 Jun 2014

Abstract excerpt

BACKGROUND: Recent work led to recognize sessile serrated adenomas (SSA) as precursor to many of the sporadic colorectal cancers with microsatellite instability (MSI). However, comprehensive analyses of DNA methylation in SSA and MSI cancer have not been conducted. METHODS: With an array-based methylation sensitive amplified fragment length polymorphism (MS-AFLP) method we analyzed 8 tubular (TA) and 19 serrated...

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PMID: 24964857
DOI: 10.1186/1471-2407-14-466

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