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Article

Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention.

Current opinion in oncology - 1 Jan 2015

Shen Chen, Vakoc Christopher R

Abstract excerpt

PURPOSE OF REVIEW: Somatic gain-of-function mutations that drive cancer pathogenesis are well established opportunities for therapeutic intervention, as demonstrated by the clinical efficacy of kinase inhibitors in kinase-mutant malignancies. Here, we discuss the recently discovered gain-of-funct...

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Share to Carcinogenesis
Share to Chromatin
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Regulator

Share to Histone-Lysine N-Methyltransferase

Share to Histone Methyltransferases

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Share to Neoplasm Proteins

Source

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Identifiers

PMID: 25402979
DOI: 10.1097/CCO.0000000000000151
PMCID: PMC4355016

Genes

NSD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25402979-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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