Article
Molecular pathways: protein methyltransferases in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2013
Copeland Robert A
Abstract excerpt
The protein methyltransferases (PMT) constitute a large and important class of enzymes that catalyze site-specific methylation of lysine or arginine residues on histones and other proteins. Site-specific histone methylation is a critical component of chromatin regulation of gene transcription-a pathway that is often genetically altered in human cancers. Oncogenic alterations (e.g., mutations, chromosomal...
Topics
- Animals
- Antineoplastic Agents
- Catalytic Domain
- Clinical Trials as Topic
- Gene Expression Regulation, Neoplastic
- Humans
- Molecular Targeted Therapy
- Mutation
- Neoplasms
- Protein Methyltransferases
- Protein Processing, Post-Translational