Article
Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment.
Nature communications - 13 Feb 2019
Hu Zhongyi, Zhou Junzhi, Jiang Junjie, Yuan Jiao, Zhang Youyou, Wei Xuepeng, Loo Nicki, Wang Yueying, Pan Yutian, Zhang Tianli, Zhong Xiaomin, Long Meixiao, Montone Kathleen T, Tanyi Janos L, Fan Yi, Wang Tian-Li, Shih Ie-Ming, Hu Xiaowen, Zhang Lin
Abstract excerpt
A growing emphasis in anticancer drug discovery efforts has been on targeting histone acetylation modulators. Here we comprehensively analyze the genomic alterations of the genes encoding histone acetylation modulator proteins (HAMPs) in the Cancer Genome Atlas cohort and observe that HAMPs have a high frequency of focal copy number alterations and recurrent mutations, whereas transcript fusions of HAMPs are...
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