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Article

Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2014

Ezponda Teresa, Licht Jonathan D

Abstract excerpt

Methylation of lysine 27 on histone H3 (H3K27me), a modification associated with gene repression, plays a critical role in regulating the expression of genes that determine the balance between cell differentiation and proliferation. Alteration of the level of this histone modification has emerged as a recurrent theme in many types of cancer, demonstrating that either excess or lack of H3K27 methylation can have...

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Identifiers

PMID: 24987060
DOI: 10.1158/1078-0432.CCR-13-2499
PMCID: PMC4184969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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