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Article

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer.

Nature reviews. Genetics - 1 Nov 2013

Plass Christoph, Pfister Stefan M, Lindroth Anders M, Bogatyrova Olga, Claus Rainer, Lichter Peter

Abstract excerpt

Malignancies are characterized by extensive global reprogramming of epigenetic patterns, including gains or losses in DNA methylation and changes to histone marks. Furthermore, high-resolution genome-sequencing efforts have discovered a wealth of mutations in genes encoding epigenetic regulators that have roles as 'writers', 'readers' or 'editors' of DNA methylation and/or chromatin states. In this Review, we...

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PMID: 24105274
DOI: 10.1038/nrg3554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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