Article
Inactivation of Epigenetic Regulators due to Mutations in Solid Tumors.
Biochemistry. Biokhimiia - 1 Jul 2020
Nemtsova M V, Mikhaylenko D S, Kuznetsova E B, Bykov I I, Zamyatnin A A
Abstract excerpt
Main factors involved in carcinogenesis are associated with somatic mutations in oncogenes and tumor suppressor genes representing changes in the DNA nucleotide sequence. Epigenetic changes, such as aberrant DNA methylation, modifications of histone proteins, and chromatin remodeling, are equally important in the development of human neoplasms. From this perspective, mutations in the genes encoding key...
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